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Bone scaffolds are essential in regenerative medicine treatments for bone defects, fractures, and disease. Despite the popularity in bone scaffold research, many challenges still remain including mechanical strength. This study focuses on compression analysis of 10 novel bone scaffold designs with each design created using Rhino 7 with the Grasshopper extension. This coding software took existing scaffold design equations and converted them into 3D models utilizing code based on previous studies. The equations were created by combining and manipulating popular equations used for bone scaffold fabrication. The scaffold models were 3D printed using SimuBone, a PLA biomaterial known for its bone-like properties and printability. The results concluded that Design 6 had the highest compression modulus and mass/density, while Design 9 had a moderate compression modulus and mass/density. Design 8 had the lowest compression modulus and Design 2 had the lowest mass/density. Additionally, Design 6 exhibits the highest stiffness but increased weight, and Design 8 performs the worst in these categories. Therefore, Design 2 was the most optimal for balancing stiffness, mass, and density. The evolution of failure between all 10 designs was also analyzed. This concluded that Design 9 and Design 6 had the highest strength with minimal collapse. Design 8 had the lowest strength with little to no collapse, while Design 2 had medium compression strength with significant collapse. Although Design 2 was found to have significant collapse, it is still considered the most optimal scaffold within this study due to having the best overall mass/density ratio and stiffness modulus with a moderate compression strength.